Rtog 0915 nrg oncology rtog 0915 ncctg n0927 a randomized phase ii study comparing 2 stereotactic body radiation therapy sbrt schedules for medically inoperable patients with stage i peripheral nonsmall cell lung cancer document history 3614 versionupdate date broadcast date amendment 4 march 6, 2014 march 19, 2014. Phase iii randomized study of concurrent chemotherapy and. Radiation therapy with or without cetuximab in treating patients who have undergone surgery for locally advanced head and neck cancer the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Patients with the following pathology findings may be treated with pelvic radiation with or without weekly cisplatin at the treating physicians discretion. An imagebased deep learning framework for individualising. If you would like to utilize this site to register a patient and have not been assigned a login name and password from nrgrtog headquarters, please access the password authorization form. Radiation therapy oncology group rtog study 0915 compared 34 gy in a single fraction to 48 gy in 4 fractions, and the roswell park institute rpci study i 124407 compared 30 gy in a single fraction to 60 gy in 3 fractions. Radiation therapy oncology group rtog 0618 a phase ii trial. Pelvic irradiation with concurrent chemotherapy versus pelvic. Rtog manuscripts and abstracts submitted for publication. Radiation therapy with or without cetuximab in treating. By clicking on accept cookies, closing this popup banner or by continuing to use the site, you agree to the use of cookies. Here, we evaluated the comparative effectiveness of surgery and sbrt in lung cancer treatment. Minor deviations from rtog 08 compliance criteria while using mc algorithms are very common and were also reported in previous studies.
Phase ii study of multiple daily fractionations in the. The vaginal internal target volume was created with use of a full and empty bladder scan. Our results signify a new roadmap for deep learningguided predictions and treatment guidance in the imagereplete and highly standardised. Your doctor may recommend this study if you have a lowgrade primary brain cancer. The final result of rtog 0915 ncctg n0927, a randomized lung stereotactic body radiation therapy trial of 34 gy in 1 fraction arm 1 versus 48 gy in 4 fractions arm 2, was that 34 gy emerged as the least toxic regimen but was equally efficacious. This study was designed to determine the efficacy and safety of these regimens in the cooperative group setting. This is an ascii program runs in a winterm or xterm window with a keyboard interface and commands, in windows a command prompt window and is invoked with the flag d followed by the directory where the rtog files are for the particular patient. Calgb 30610 rtog 0538 limited small cell 45 gy bid 3 weeks 61.
Pmid 11702729 2001 rtog publications since 1996 ijrobp vol 51 no 3 suppl 2, 125145, 2001. Stereotactic body radiation therapy sbrt has been proposed as a potential alternative to surgery for early lung cancer, although we lack wellpowered prospective randomized data comparing these treatments, and existing studies suffer from incomplete information on confounders that can bias results. We use cookies to give you the best possible user experience. May 16, 2016 per treating physicians discretion, a choice of 2 chemotherapy regimens. Patients with spine metastasis with a numerical rating pain scale nrps score. Longterm followup on nrg oncology rtog 0915 ncctg n0927. For rtog 8502, there were 32 patients alive at 9 months and 19 patients alive at 12 months available for evaluation of late toxicity. Rtog 0915 12gy x 4 vs 30gy x 1 showed equivalent control results 97% lc in both arms. The decision to add weekly cisplatin for these patients is at the treating physicians discretion. Survival and toxicities of imrt based on the rtog protocols. As of may 2001 ijrobp vol 51 no 3 suppl 2, 1468, 2001. Combination chemotherapy and radiation therapy withwithout. Our results indicate that there are imagedistinct subpopulations that have differential sensitivity to radiotherapy.
May 01, 20 rtog 0418 specified that the pelvic lymphatics were contoured according to rtog guidelines. Radiation therapy oncology group rtog study 0915 compared 34 gy in a single fraction to 48 gy in 4 fractions, and the roswell park institute rpci study i 124407 compared 30. Here, we evaluated the comparative effectiveness of surgery and sbrt in lung cancer. However, it is imperative to apply these protocols to patients from the areas of china where npc is endemic, and further assess longterm survival and late toxicities. The protocol specified a 7mm expansion on these volumes to generate a planning target volume ptv, and 50. Paclitaxel and carboplatin weekly for 6 weeks followed by 2 cycles of consolidation. Rtog 0631 phase 23 study of image guided stereotactic.
Rtog 0233 cdr0000258303 ecogr0233 nci201101578 registry identifier. Radiation treatment planning with embedded dose escalation. Nrg oncology rtog 6 a randomized phase ii study of. Radiation oncologyrtog trials wikibooks, open books for an. Pelvic irradiation with concurrent chemotherapy versus. Radiation therapy oncology group rtog 0618 a phase ii trial of stereotactic body radiation therapy sbrt in the treatment of patients with operable stage iii nonsmall cell lung cancer study chairs 2409 principal investigatorradiation oncologyigrt robert d.
Please visit the rtog website for the latest trials and protocol information. Drugs used in chemotherapy, such as cisplatin, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Multicenter evaluation of dose conformity in stereotactic. It is intended to be used only in conjunction with institutionspecific irb approval for study entry. The rtog 0225 and rtog 0615 protocols for npc provided good treatment outcomes and acceptable rtrelated toxicities in patients from the nonendemic regions 12. Ctrp clinical trial reporting program first posted. A randomized phase 2 study comparing 2 stereotactic body radiation. Dec 19, 2017 rtog 0236 and rtog 0915 prospectively evaluated sbrt in medically inoperable patients. Activated rtog 0915 ncctg n0927, a randomized phase ii study comparing 2 stereotactic body radiation therapy sbrt schedules for medically inoperable patients with stage i. Grignon d, pajak t, hammond e, et al application of the gleason grading system.
Assessment of monte carlo algorithm for compliance with rtog. Radiation oncologyrtog trials8531 wikibooks, open books. Cisplatin and etoposide, every 4 weeks, for 2 cycles. Starting october 1, 2010, all adverse events aes for rtog 0915 must be reported using ctcae version 4.
Rtog 0236 and rtog 0915 prospectively evaluated sbrt in medically inoperable patients. Rtog 0631 radiation therapy oncology group rtog 0631 phase iiiii study of imageguided radiosurgerysbrt for localized spine metastasis study chairs principal investigatorradiation oncology samuel ryu, md henry ford hospital 2799 w. Oct 21, 2016 angiogenesis, a hallmark of glioblastoma, can potentially be targeted by inhibiting the vegf pathway using bevacizumab, a humanized monoclonal antibody against vegfa. We are a leading protocol organizations within the national clinical trials network and we seek to improve the. If you would like to utilize this site to register a patient and have not been assigned a login name and password from nrg rtog headquarters, please access the password authorization form. Contouring atlases anorectal bladder atlas brachial plexus contouring atlas. This site will allow users to register a patient or enter case form data directly to a nrg rtog study twentyfour 24 hours a day, seven 7 days a week. Rtog is funded by national cancer institute grant numbers. According to the most recent statistics released by the american cancer society, lung cancer will be the second most commonly diagnosed cancer in 20, with an estimation of 118,080 and 110,110 new cases in men and women, respectively. Aug 11, 2009 radiation therapy with or without cetuximab in treating patients who have undergone surgery for locally advanced head and neck cancer the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Recently published results from the longterm followup of radiation therapy oncology group rtog trial 9802 demonstrated medically meaningful. Angiogenesis, a hallmark of glioblastoma, can potentially be targeted by inhibiting the vegf pathway using bevacizumab, a humanized monoclonal antibody against vegfa. Jan 07, 20 recently published results from the longterm followup of radiation therapy oncology group rtog trial 9802 demonstrated medically meaningful and statistically significant survival prolongation. A randomized phase iii clinical trial evaluating postmastectomy chestwall and regional nodal xrt and postlumpectomy regional nodal xrt in patients with positive axillary nodes before neoadjuvant chemotherapy who convert to pathologically negative axillary nodes after neoadjuvant chemotherapy.
Rtog 0418 specified that the pelvic lymphatics were contoured according to rtog guidelines. University of texas southwestern 5801 forest park road, nf3. The prescription isodoses for the plans were kept to between 59% and 90% as recommended by rtog 11 and ding et al. Videtic and others published radiation therapy oncology group rtog protocol 0915. Rtog and authors are not responsible for any use of these guidances by third parties. The materials presented on this website illustrate the consensus reached among cooperative groups and disease site committees. Clinical trials system american college of radiology. Rtog 0618 a phase ii trial of sbrt in the treatment of patients with operable stage iii nonsmall cell lung cancer rtog 08 seamless phase iii study of sbrt for early stage, centrally located, nonsmall cell lung cancer in medically operable patients rtog 0236 has something for everyone anatomy definition oar constraints. The management of lung cancer american society for. There has been one late grade 3 gi toxicity reported and only one acute grade 3 gastrointestinal toxicity. Radiation therapy oncology group rtog protocol 0915. Threedimensional descriptions of the lung, proximal bronchial tree, esophagus, spinal cord, ribs, and brachial plexus are presented. Nov 29, 2017 stereotactic body radiation therapy sbrt has been proposed as a potential alternative to surgery for early lung cancer, although we lack wellpowered prospective randomized data comparing these treatments, and existing studies suffer from incomplete information on confounders that can bias results.
The radiation therapy oncology group has completed 2 trials rtog 0614 and 0933 aimed at reducing the toxicity of wbrt. Surgery versus stereotactic body radiation therapy for stage. Radiation and chemotherapy with or without an experimental drug rad001 your doctor may recommend this study following surgery for a high grade primary brain cancer glioblastoma rtog 0925. Rtog 0915, amended amended rtog 0915, a randomized phase ii study comparing 2 stereotactic body radiation therapy sbrt schedules for medically inoperable patients with stage i peripheral nonsmall cell lung cancer amendment 2. No other use or reproduction is authorized by rtog nor does rtog assume. Stereotactic body radiation therapy versus surgery for early. Consideration of dose limits for organs at risk of thoracic. Evaluation of acuros xb algorithm based on rtog 08. Mild tightness of skin and itching may occur to promote hydrated skin, patient comfort and maintain skin integrity. This site will allow users to register a patient or enter case form data directly to a nrgrtog study twentyfour 24 hours a day, seven 7 days a week. The imagebased deep learning framework proposed herein is the first opportunity to use medical images to individualise radiotherapy dose. The need for central pathology tumor grading in prostate cancer using radiation therapy oncology group rtog 8531.
Rtog 0614 was a randomized trial of wbrt versus wbrt and memantine in patients with brain metastases and showed better cognitive function over time in the memantine group. Secondary analysis of rtog 9508, a phase 3 randomized trial. The effect of beam arrangements and the impact of non. In rtog 7905, 90% of the late toxicities appeared by 12 months. Effect of tumor location and dosimetric predictors for chest. Two prospective, randomized, phase 2 trials investigated the safety and efficacy of sfsbrt.
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